| Autoimmune disease | Immunopathogenesis and potential immunotherapies of autoimmune diseases (multiple sclerosis, uveoretinitis, rheumatoid arthritis) | Hui Rong Jiang |
| | MRL/lpr model of Systemic Lupus Erythrematosus (SLE). Collagen-induced arthritis in DBA/1 and B6 mice. Arthriogenic-antibody model of arthritis. Ovalbumin-induced model of airway inflammation. DSS-model of colitis. Facilities for in situ imaging using laser scanning cytometry to track responses of individual cells within their physiological niche in tissues. | Margaret Harnett |
| | Freunds adjuvant monoarthritis; collagen-induced arthritis; surgically-induced osteoarthritis; all in rats and in mice. Facilities for laser Doppler imaging to assess synovial perfusion in mice and rats, which allows dose response analysis of vasoactive and other agents. | Available upon request |
| | Adjuvant-induced arthritis in rat (T lymphocyte-mediated delayed hypersensitivity reaction). Carrageenin-induced paw oedema in mice and rats (non-immune acute inflammatory reaction). | Pasquale Maffia |
| Helminth parasites | Structure, synthesis, enzymatic function, immunomodulatory activity and therapeutic potential of the anti-inflammatory molecule, ES-62, a phosphorylcholine-containing glycoprotein secreted by the parasitic filarial nematode Acanthocheilonema vitea. | Available upon request |
| | Gastrointetinal parasitic helminths on the immune system of the host. | Catherine Lawrence |
| Immune cell/cytokine deletions | IL-4Ralpha-/-mice IL-4-/-mice Macrophage/neutrophil soecific IL-4Ralpha-/- mice CD4+ Tcell specific IL-4Ra-/- mice CD4+ and CD8+ T cellspecific IL- 4Ra-/- mice | Jim Alexander |
| Infectious disease | Bacterial pneumonia, sepsis and middle ear infection The models are used to evaluate new treatments and vaccines for infectious diseases. | Tim Mitchell |
| Inflammatory disease | MRL/lpr model of Systemic Lupus Erythrematosus (SLE), and the NZW/NZB model of this pathology. Collagen-induced arthritis in DBA/1 and B6 mice 3. Arthritogenic-antibody model of arthritis 4. Ovalbumin-induced model of airway inflammation 5. DSS-model of colitis. | Margaret Harnett |
| | Mouse Model of Dextran Sodium Sulphate (DSS) Colitis A useful model for studying inflammatory bowel disease. | Allan Mowat |
| | Further model of arthritis in mice and rats | Available upon request |
| | Adjuvant-induced arthritis in rat Is and experimental immunopathy, involving T lymphocyte-mediated delayed hypersensitivity reaction, that exhibits many similarities to human rheumatoid arthritis. This has become one of the standard models for studying the anti-inflammatory/anti-rheumatic properties of compounds.Carrageenin-induced paw oedema (mice and rats) Carrageenin-induced paw oedema is a model of non-immune acute inflammatory reaction to assess the contribution of mediators involved in vascular changes associated with acute inflammation and potential treatements. OVA-induced arthritis model (mouse) A model of the early stages of the induction of arthritis which can be induced with trackable TcR tg T cells and shows important novel features such as breach of self tolerance. | Paul Garside James Brewer Iain McInnes Pasquale Maffia |
| | Ovine model of Polycystic Ovary Disease | Jane Robinson |
| Microbial infection | Mouse models for bacterial pneumonia, sepsis and middle ear infection; used to evaluate new treatments and vaccines for infectious diseases; in vivo imaging to monitor progression of infection in live animals (bioluminescent bacteria and/or fluorescent gene reporters); telemetry to monitor core body temperature and movement of infected animals. | Tim Mitchell |
| Protozoan parasites | Interaction of the immune system with intracellular protozoan parasites, particularly Leishmania and Toxoplasma gondii and development of vaccines; vaccine adjuvants | Jim Alexander |
| | Delivery systems to improve the treatment of leishmaniasis | Chris Carter |
| | The shikimate pathway and fatty acid synthesis as novel drug targets in Apicomplexan parasites (eg Toxoplasma); immunological control of Toxoplasma; antimicrobial agents for treatment of Acanthameoba | Craig Roberts |
